Antibiotic Resistance Mediated by the MacB ABC Transporter Family: A Structural and Functional Perspective
The MacB ABC transporter forms a tripartite efflux pump with the MacA adaptor protein and TolC outer membrane exit duct to expel antibiotics and export virulence factors niner rkt 9 rdo 2023 from Gram-negative bacteria.Here, we review recent structural and functional data on MacB and its homologs.MacB has a fold that is distinct from other structur